|
Product |
Problem |
FMC Approach |
Results |
|
Adult Chewable Acetaminophen Tablet |
Gritty, chalky mouthfeel |
Add 10% Avicel CE-15 in place of like amount of mannitol |
Improve overall mouthfeel; less grittiness, chalkiness, toothpacking; perceived better taste |
|
Adult Chewable Antacid Tablet |
Extreme hardness (22Kp), high friability (1.5%) |
Softer tablet (9Kp) and reduced friability (0.5%) |
|
|
Adult Chewable Aspirin Tablet |
gritty mouthfeel, chalky residue |
Add 10% Avicel CE-15 , allowing for removel of 0.7 grams of other excipients (40% reduction in exipient usage) |
smaller tablet; improved mouthfeel; friablilty reduced from 1.25% to 0.9% |
|
Large Chewable Antacid Tablet |
Large 2 gram size, poor mouthfeel, high friabaility |
Add 3% Avicel CE-15, allowing for removel of 0.7 grams of other exipients (40% reduction in exipient usage) |
smaller tablet; improved mouthfeel; friablilty reduced from 1.25% to 0.9% |
|
Chewable Antacid Tablet |
Poor overall mouthfeel |
Add 2% Avicel CE-15 in palce of like amount of mannitol |
overall snesory performance improved |
